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Thesis

Single-molecule chemistry studies with engineered alpha-hemolysin pores

Abstract:

Engineered protein nanopores can be used to investigate a wide range of dynamic processes in real time and at the single-molecule level, for example covalent bond making and breaking or the interaction of ligands with their cognate binding sites. The detection of such processes is accomplished by monitoring the current carried by ions through the pore in an applied potential, which is modulated as molecules of interest interact with engineered binding sites within the pore. In contrast to ...

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Institution:
University of Oxford
Oxford college:
Balliol College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology

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Role:
Supervisor
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Funding agency for:
Anne Friederike Hammerstein
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:1dd1f11d-2b20-42e9-9dfc-c30498822b77
Local pid:
ora:10754

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