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Journal article

Unusual molecular architecture of the machupo virus attachment glycoprotein

Abstract:

New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel alpha/beta fold. This provides a blueprint of the New World arenavirus attachm...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/jvi.00761-09

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of virology
Volume:
83
Issue:
16
Pages:
8259-8265
Publication date:
2009-08-01
Acceptance date:
2009-05-26
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
20279
Language:
English
Keywords:
Pubs id:
pubs:20279
UUID:
uuid:1dcd7c4c-9d67-4e89-be85-a6971c6e4a6a
Local pid:
pubs:20279
Deposit date:
2012-12-19

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