Journal article icon

Journal article

Unusual molecular architecture of the machupo virus attachment glycoprotein

Abstract:

New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel alpha/beta fold. This provides a blueprint of the New World arenavirus attachm...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1128/jvi.00761-09

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Expand authors...
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of virology Journal website
Volume:
83
Issue:
16
Pages:
8259-8265
Publication date:
2009-08-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:1dcd7c4c-9d67-4e89-be85-a6971c6e4a6a
Source identifiers:
20279
Local pid:
pubs:20279

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP