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Journal article

Selectivity and cooperativity of modulatory ions in a neurotransmitter receptor.

Abstract:

Ions play a modulatory role in many proteins. Kainate receptors, members of the ionotropic glutamate receptor family, require both monovalent anions and cations in the extracellular milieu for normal channel activity. Molecular dynamics simulations and extensive relative binding free energy calculations using thermodynamic integration were performed to elucidate the rank order of binding of monovalent cations, using x-ray crystal structures of the GluR5 kainate receptor dimers with bound cati...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2008.11.039

Authors


Vijayan, R More by this author
Plested, AJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Biophysical journal
Volume:
96
Issue:
5
Pages:
1751-1760
Publication date:
2009-03-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:1dcd0d43-66c7-48cb-88b5-f06e1ac9853f
Source identifiers:
100022
Local pid:
pubs:100022

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