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Subunit dynamics and nucleotide-dependent asymmetry of an AAA+ transcription complex

Abstract:

Bacterial enhancer binding proteins (bEBPs) are transcription activators that belong to the AAA+ protein family. They form higher-order self-assemblies to regulate transcription initiation at stress response and pathogenic promoters. The precise mechanism by which these ATPases utilize ATP binding and hydrolysis energy to remodel their substrates remains unclear. Here we employed mass spectrometry of intact complexes to investigate subunit dynamics and nucleotide occupancy of the AAA+ domain ...

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Publisher copy:
10.1016/j.jmb.2013.08.018

Authors


Journal:
Journal of Molecular Biology More from this journal
Volume:
426
Issue:
1
Pages:
71-83
Publication date:
2014-01-09
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Language:
English
Keywords:
Pubs id:
pubs:445952
UUID:
uuid:1dcb2b93-ab00-49f9-adf8-96fec4ee8663
Local pid:
pubs:445952
Source identifiers:
445952
Deposit date:
2014-02-08

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