Journal article icon

Journal article

In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy

Abstract:

Tuberculosis (TB) continues to pose a serious global health threat, and the current vaccine, BCG, has variable efficacy. However, the development of a more effective vaccine is severely hampered by the lack of an immune correlate of protection. Candidate vaccines are currently evaluated using preclinical animal models, but experiments are long and costly and it is unclear whether the outcomes are predictive of efficacy in humans. Unlike measurements of single immunological parameters, mycobac...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.vaccine.2016.07.058

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
European Research Infrastructures for Poverty Related Diseases More from this funder
Universities Federation for Animal Welfare More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
34
Issue:
39
Pages:
4656-4665
Publication date:
2017-08-12
Acceptance date:
2017-07-29
DOI:
ISSN:
1873-2518
Keywords:
Pubs id:
pubs:637966
UUID:
uuid:1dc21241-a889-4f73-97ff-3c4080951e65
Local pid:
pubs:637966
Deposit date:
2016-08-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP