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In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy

Abstract:

Tuberculosis (TB) continues to pose a serious global health threat, and the current vaccine, BCG, has variable efficacy. However, the development of a more effective vaccine is severely hampered by the lack of an immune correlate of protection. Candidate vaccines are currently evaluated using preclinical animal models, but experiments are long and costly and it is unclear whether the outcomes are predictive of efficacy in humans. Unlike measurements of single immunological parameters, mycobac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.vaccine.2016.07.058

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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
Universities Federation for Animal Welfare More from this funder
European Research Infrastructures for Poverty Related Diseases More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
34
Issue:
39
Pages:
4656-4665
Publication date:
2017-08-12
Acceptance date:
2017-07-29
DOI:
ISSN:
1873-2518
Pubs id:
pubs:637966
URN:
uri:1dc21241-a889-4f73-97ff-3c4080951e65
UUID:
1dc21241-a889-4f73-97ff-3c4080951e65
Local pid:
pubs:637966

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