Journal article icon

Journal article

A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo.

Abstract:

(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clinically as a PET agent both for delineation of tumor hypoxia and as an effective indicator of patient prognosis, but there are still aspects of the mechanism of action that are not fully understood.The retention of radioactivity in tumors after administration of (64)Cu-ATSM in vivo is substantially higher for tumors with a significant hypoxic fraction. This hypoxia-dependent retention is believed...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.2967/jnumed.113.119917

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst For Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Expand authors...
CR-UK/EPSRC Cancer Imaging Centre More from this funder
Cancer Research UK More from this funder
GlaxoSmithKline More from this funder
Gray Laboratory Research Trust More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
Society of Nuclear Medicine Publisher's website
Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
Volume:
55
Issue:
1
Pages:
128-134
Publication date:
2014-01-01
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:1db13ad7-3d1e-4239-8f21-71eaf038342d
Source identifiers:
444165
Local pid:
pubs:444165

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP