Journal article
BK ablation attenuates osteoblast bone formation via integrin pathway
- Abstract:
-
Impaired bone formation is one of the major causes of low bone mass and skeletal fragility that occurs in osteoporosis. However, the mechanisms underlying the defects in bone formation are not well understood. Here, we report that big conductance calcium-activated potassium channels (BKs) are required for bone formation and osteoblast function both in vivo and in vitro. By 15 weeks of age, BK knockout (BKO) mice exhibited a decline in bone mineral density and trabecular bone volume of the tib...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Cell Death and Disease Journal website
- Volume:
- 10
- Article number:
- 738
- Publication date:
- 2019-09-30
- Acceptance date:
- 2019-09-05
- DOI:
- EISSN:
-
2041-4889
- ISSN:
-
2041-4889
- Pmid:
-
31570694
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1059789
- Local pid:
- pubs:1059789
- Deposit date:
- 2020-03-11
Terms of use
- Copyright holder:
- Wang et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) 2019. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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