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BK ablation attenuates osteoblast bone formation via integrin pathway

Abstract:

Impaired bone formation is one of the major causes of low bone mass and skeletal fragility that occurs in osteoporosis. However, the mechanisms underlying the defects in bone formation are not well understood. Here, we report that big conductance calcium-activated potassium channels (BKs) are required for bone formation and osteoblast function both in vivo and in vitro. By 15 weeks of age, BK knockout (BKO) mice exhibited a decline in bone mineral density and trabecular bone volume of the tib...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41419-019-1972-8

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Name:
National Natural Science Foundation of China (National Science Foundation of China)
Grant:
81370979
Publisher:
Springer Nature
Journal:
Cell Death and Disease More from this journal
Volume:
10
Article number:
738
Publication date:
2019-09-30
Acceptance date:
2019-09-05
DOI:
EISSN:
2041-4889
ISSN:
2041-4889
Pmid:
31570694
Language:
English
Keywords:
Pubs id:
1059789
Local pid:
pubs:1059789
Deposit date:
2020-03-11

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