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Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia.

Abstract:

Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A quantitative expression profile analysis of 157 mature miRNAs was performed on 100 AML patients representing the spectrum of known karyotypes common in AML. The principle observation reported here is that AMLs bearing a t(15;17) translocation had a distinctive signature throughout the whole set of genes, including the up regulation of a subse...

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Publisher copy:
10.1371/journal.pone.0002141

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
PloS one More from this journal
Volume:
3
Issue:
5
Pages:
e2141
Publication date:
2008-01-01
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:1dadb4b7-5763-4a8c-ba95-e511ab1b8619
Local pid:
pubs:291685
Source identifiers:
291685
Deposit date:
2012-12-19

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