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Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation.

Abstract:

BACKGROUND: Toll-like receptors (TLRs) have long been considered to be major culprits in the development of atherosclerosis, contributing both to its progression and clinical complications. However, evidence for most TLRs beyond TLR2 and TLR4 is lacking. METHODS AND RESULTS: We used experimental mouse models, human atheroma cultures, and well-established human biobanks to investigate the role of TLR7 in atherosclerosis. We report the unexpected finding that TLR7, a receptor recognizing self-...

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Publication status:
Published

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Journal:
Circulation More from this journal
Volume:
126
Issue:
8
Pages:
952-962
Publication date:
2012-08-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Language:
English
Keywords:
Pubs id:
pubs:342388
UUID:
uuid:1da60033-6ccc-4279-95a4-819a4ed30cc4
Local pid:
pubs:342388
Source identifiers:
342388
Deposit date:
2013-11-16

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