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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

Abstract:

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in the pancreatic beta cells are decisive for their survival or death in diabetes. We have used RNA sequencing (RNA-seq) to identify transcripts, including splice variants, expressed in human islets of Langerhans under control conditions or following exposure to the pro-inflammatory cytokines interleukin-1β (...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pgen.1002552

Authors


Eizirik, DL More by this author
Sammeth, M More by this author
Bouckenooghe, T More by this author
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Journal:
PLoS genetics
Volume:
8
Issue:
3
Pages:
e1002552
Publication date:
2012
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:1d9f9292-cf54-48ea-9f96-e3a3e689fa4d
Source identifiers:
316240
Local pid:
pubs:316240

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