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Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder.

Abstract:

There is evidence for both similarity and distinction in the presentation and molecular characterization of schizophrenia and bipolar disorder. In this study, we characterized protein abnormalities in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder using two-dimensional gel electrophoresis. Tissue samples were obtained from 35 individuals with schizophrenia, 35 with bipolar disorder and 35 controls. Eleven protein spots in schizophrenia and 48 in bipolar disorder were...

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Publication status:
Published

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Publisher copy:
10.1038/sj.mp.4002098

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Journal:
Molecular psychiatry
Volume:
13
Issue:
12
Pages:
1102-1117
Publication date:
2008-12-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:1d9d96b8-6cf0-4143-a4d3-e2812c8d72ac
Source identifiers:
200687
Local pid:
pubs:200687

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