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Gene expression profile of human cells irradiated in G1 and G2 phases of cell cycle.

Abstract:

The response of cells to ionizing radiation has long been known to result in alterations in gene expression. Here we examined the expression patterns of synchronized HeLa cells in G1 or G2, after exposure to 2Gy of X-rays on microarrays allowing evaluation of over 12,000 human genes. The analysis showed induction of at least twofold for 257 different genes, after irradiation of cells in G1 and down-regulation of 42. The altered transcription patterns involved genes belonging to cell cycle pat...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Cancer letters
Volume:
195
Issue:
2
Pages:
221-233
Publication date:
2003-06-05
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:1d9c4468-92e3-4a27-a61e-c1983b9af247
Source identifiers:
118191
Local pid:
pubs:118191

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