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Journal article

Mutations in normal breast tissue and breast tumours.

Abstract:

The accumulation of mutations is a feature of all normal cells. The probability of any individual gene in any cell acquiring a mutation is, however, low. Cancer is therefore a rare disease in comparison with the number of susceptible cells. Mutations in normal tissue are stochastic, vary widely among cells and are therefore difficult to detect using standard methods because each change is so rare. If, however, a tissue such as the breast undergoes considerable clonal expansion, particularly i...

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Publisher copy:
10.1186/bcr311

Authors


Tomlinson, IP More by this author
Journal:
Breast cancer research : BCR
Volume:
3
Issue:
5
Pages:
299-303
Publication date:
2001
DOI:
EISSN:
1465-542X
ISSN:
1465-5411
URN:
uuid:1d978f9e-08c4-419d-aaf9-69b6548c10c6
Source identifiers:
72197
Local pid:
pubs:72197

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