- Abstract:
-
AIMS/HYPOTHESIS: We investigated the pharmacological properties of two novel ATP sensitive potassium (K(ATP)) channel openers, 6-Chloro-3-isopropylamino-4 H-thieno[3,2- e]-1,2,4-thiadiazine 1,1-dioxide (NNC 55-0118) and 6-chloro-3-(1-methylcyclopropyl)amino-4 H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (NN414), on the cloned cardiac (Kir6.2/SUR2A), smooth muscle (Kir6.2/SUR2B) and pancreatic beta cell (Kir6.2/SUR1) types of K(ATP) channel. METHODS: We studied the effects of these compounds ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00125-003-1198-1
-
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- Journal:
- Diabetologia
- Volume:
- 46
- Issue:
- 10
- Pages:
- 1375-1382
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
-
1432-0428
- ISSN:
-
0012-186X
- URN:
-
uuid:1d88a04b-75b5-4001-8d32-6f350bbd78b6
- Source identifiers:
-
113940
- Local pid:
- pubs:113940
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.
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