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Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

Abstract:

AIMS/HYPOTHESIS: We investigated the pharmacological properties of two novel ATP sensitive potassium (K(ATP)) channel openers, 6-Chloro-3-isopropylamino-4 H-thieno[3,2- e]-1,2,4-thiadiazine 1,1-dioxide (NNC 55-0118) and 6-chloro-3-(1-methylcyclopropyl)amino-4 H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (NN414), on the cloned cardiac (Kir6.2/SUR2A), smooth muscle (Kir6.2/SUR2B) and pancreatic beta cell (Kir6.2/SUR1) types of K(ATP) channel. METHODS: We studied the effects of these compounds ...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-003-1198-1

Authors


Dabrowski, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Bondo Hansen, J More by this author
Journal:
Diabetologia
Volume:
46
Issue:
10
Pages:
1375-1382
Publication date:
2003-10-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:1d88a04b-75b5-4001-8d32-6f350bbd78b6
Source identifiers:
113940
Local pid:
pubs:113940

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