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Humoral and cellular responses raised against the human HER2 oncoprotein are cross-reactive with the homologous product of the new proto-oncogene, but do not protect rats against B104 tumors expressing mutated neu.

Abstract:

The neu proto-oncogene encodes a plasma membrane protein belonging to the epidermal growth factor receptor family. The cell line B104, derived from BDIX rat neuroblastoma, carries a point mutation in neu, and forms a tumor when injected into these rats. The human homologue of the neu oncogene (here called HER2) is overexpressed in certain types of cancer. Rats were immunized with HER2 protein (HER2) to investigate a possible cross-reaction between the homologous proteins which could protect t...

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Publication status:
Published

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Publisher copy:
10.1007/s002620050268

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Cancer immunology, immunotherapy : CII
Volume:
42
Issue:
3
Pages:
179-184
Publication date:
1996-03-05
DOI:
EISSN:
1432-0851
ISSN:
0340-7004
URN:
uuid:1d85bf95-bc5b-45db-82b4-14800257262a
Source identifiers:
481697
Local pid:
pubs:481697

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