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Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain.

Abstract:

OBJECTIVE: The mechanism of action of anti-B cell therapy in multiple sclerosis (MS) is not fully understood. Here, we compared the effect of anti-CD20 therapy on microglial activation in two distinct focal rat models of MS. METHODS: The effect of anti-CD20 therapy on lesion formation and extralesional microglial activation was evaluated in the fDTH-EAE (experimental allergic encephalomyelitis) model, which is a focal demyelinating type-IV delayed-type hypersensitivity lesion. For comparison,...

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Publisher copy:
10.1002/acn3.94

Authors


Journal:
Annals of clinical and translational neurology More from this journal
Volume:
1
Issue:
9
Pages:
659-669
Publication date:
2014-09-01
DOI:
EISSN:
2328-9503
Language:
English
Pubs id:
pubs:492865
UUID:
uuid:1d842056-dabd-497f-8202-b5013adb544c
Local pid:
pubs:492865
Source identifiers:
492865
Deposit date:
2014-12-26

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