Macrophage-matrix interactions in the breast tumour microenvironment: the case of tenascin-C

Thesis

Tumour-associated macrophages (TAMs) are key immune-suppressive constituents of the breast tumour microenvironment (TME) and correlate with poor prognosis. Tenascin-C (TNC) is an immunomodulatory extracellular matrix (ECM) protein which is upregulated in breast tumours, and is associated with increased metastasis and worsened prognosis. Our previous work showed that perturbation of the breast TME by tumour-derived TNC skews macrophages towards an immune-suppressive phenotype featuring downreg...

Expand abstract

Authors: Gammage, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: scRNAseq; TNC; tumour microenvironment; breast cancer; macrophage; TAM; epigenetics; tenascin-C; extracellular matrix; KDM6B; single-cell RNAseq; tumour-associated macrophage; ECM