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Thesis

Structural and bioenergetic changes in tumour spheroids during growth

Abstract:

Multicellular tumour spheroids (TS) are an in vitro model of avascular tumours, and have been widely used to investigate tumour growth, metabolism and hypoxia. The geometry of the TS lends itself to mathematical representation, and theoretical models of TS growth and the development of hypoxia are abundant. With some notable exceptions however, these models have been developed independently of the biological data collection process and are overwhelmingly based upon data from multi...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Medical Sciences Division - Clinical Laboratory Sciences

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1d7b8669-b62a-4554-bb66-157f54e3ded2
Local pid:
ora:12086

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