Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults.

Journal article

BACKGROUND: In mice, highly repetitive antigens, such as those present on bacterial or viral surfaces, efficiently cross-link B-cell receptors and therefore induce strong IgG responses. In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Qbeta (Qbeta-Der p 1). OBJECTIVE: We evaluated the safety and immunogenicity of Qbeta-Der p 1 in human subjects and compared different doses and routes of immu...

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Authors: Kündig, T; Senti, G; Schnetzler, G; Wolf, C; Prinz Vavricka, B

• Publication status: Published
• Journal: Journal of allergy and clinical immunology
• Volume: 117
• Issue: 6
• Pages: 1470-1476
• Publication date: 2006-06-01
• DOI: 10.1016/j.jaci.2006.01.040
• EISSN: 1097-6825
• ISSN: 0091-6749
• Language: English
• Keywords: Amino Acid Sequence; Arthropod Proteins; Female; Viral Vaccines; Molecular Sequence Data; Antibodies, Viral; Adult; Cysteine Endopeptidases; Allolevivirus; Animals; Male; Antigens, Dermatophagoides; Immunoglobulin G; Vaccines, Combined; Peptide Fragments; Virion; Humans; Adolescent; Hepatitis B Core Antigens; Hepatitis B Vaccines; Middle Aged; Pyroglyphidae