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Journal article

Actin and microtubule regulation of trans-Golgi network architecture, and copper-dependent protein transport to the cell surface.

Abstract:

The Menkes disease ATPase (MNK) is a copper transporter that localizes to the mammalian trans-Golgi network (TGN) and shows substantial co-localization wih a ubiquitous TGN resident protein and marker, TGN46. We tested our hypothesis that these two TGN residents and integral membrane proteins are localized to biochemically distinct TGN sub-compartments using constitutively active mutant proteins and drugs that disrupt membrane traffic, lumenal pH and the cellular cytoskeleton. The pH-disrupti...

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Publication status:
Published

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Publisher copy:
10.1080/096870310001607350

Authors


Cobbold, C More by this author
Coventry, J More by this author
Ponnambalam, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Molecular membrane biology
Volume:
21
Issue:
1
Pages:
59-66
Publication date:
2004
DOI:
EISSN:
1464-5203
ISSN:
0968-7688
URN:
uuid:1d766376-be5a-4087-9d27-bb24b601d616
Source identifiers:
32574
Local pid:
pubs:32574

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