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Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.

Abstract:

BACKGROUND and AIMS: Recent genome-wide association studies have identified common low-risk variants for colorectal cancer (CRC). To assess whether these influence CRC risk in the Lynch syndrome, we genotyped these variants in a large series of proven mutation carriers. METHODS: We studied 675 individuals from 127 different families from the Dutch Lynch syndrome Registry whose mutation carrier status was known. We genotyped 8q24.21, 8q23.3, 10p14, 11q23.1, 15q13.3, and 18q21.1 variants in ca...

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Publication status:
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Authors


Wijnen, JT More by this author
Brohet, RM More by this author
van Eijk, R More by this author
Jagmohan-Changur, S More by this author
Middeldorp, A More by this author
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Journal:
Gastroenterology
Volume:
136
Issue:
1
Pages:
131-137
Publication date:
2009-01-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:1d744648-aadb-4ea4-8f53-05ddfe473ffa
Source identifiers:
72275
Local pid:
pubs:72275

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