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Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.

Abstract:

Activating transcription factor 6 (ATF6) is located within the region of linkage to type 2 diabetes on chromosome 1q21-q23 and is a key activator of the endoplasmic reticulum stress response. We evaluated 78 single nucleotide polymorphisms (SNPs) spanning >213 kb in 95 people, from which we selected 64 SNPs for evaluation in 191 Caucasian case subjects from Utah and between 165 and 188 control subjects. Six SNPs showed nominal associations with type 2 diabetes (P = 0.001-0.04), including t...

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Publication status:
Published

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Publisher copy:
10.2337/db06-1305

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Journal:
Diabetes
Volume:
56
Issue:
3
Pages:
856-862
Publication date:
2007-03-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:1d6cd290-cdcb-4a37-9619-eaf4587220ff
Source identifiers:
18046
Local pid:
pubs:18046

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