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An induced rebinding model of antigen discrimination.

Abstract:

T cells have to detect rare high-affinity 'foreign' peptide MHC (pMHC) ligands among abundant low-affinity 'self'-peptide MHC ligands. It remains unclear how this remarkable discrimination is achieved. Kinetic proofreading mechanisms can provide the required specificity but only at the expense of much reduced sensitivity. A number of recent observations suggest that pMHC engagement of T cell receptors (TCRs) induces changes such as clustering and/or conformational alterations that enhance sub...

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Publication status:
Published

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Publisher copy:
10.1016/j.it.2014.02.002

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Trends in immunology
Volume:
35
Issue:
4
Pages:
153-158
Publication date:
2014-04-05
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
URN:
uuid:1d6c0399-1816-4b04-baa2-d133b5dfe8df
Source identifiers:
457651
Local pid:
pubs:457651
Language:
English

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