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Journal article

Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line.

Abstract:

Observed mutation rates in humans appear higher in male than female gametes and often increase with paternal age. This bias, usually attributed to the accumulation of replication errors or inefficient repair processes, has been difficult to study directly. Here, we describe a sensitive method to quantify substitutions at nucleotide 755 of the fibroblast growth factor receptor 2 (FGFR2) gene in sperm. Although substitution levels increase with age, we show that even high levels originate from ...

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Publication status:
Published

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Publisher copy:
10.1126/science.1085710

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Science (New York, N.Y.) More from this journal
Volume:
301
Issue:
5633
Pages:
643-646
Publication date:
2003-08-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075

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