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Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology

Abstract:

Clonality studies greatly assist in the diagnosis of challenging haematopathology cases. These robust and standardised tests aid the detection of clonal lymphoid populations and may assist in lymphocyte subtyping. In this case report, a gentleman presented with a high-grade transformation of a B cell neoplasm which histologically and immunophenotypically mimicked a T cell anaplastic large-cell lymphoma. With the aid of T cell and B cell receptor clonality studies, it was demonstrated that thi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1007/s12308-016-0280-9

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
ORCID:
0000-0001-6344-9081
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Clinical Laboratory Sciences
Publisher:
Springer Publisher's website
Journal:
Journal of Hematopathology Journal website
Volume:
9
Issue:
3
Pages:
143-147
Publication date:
2016-08-08
Acceptance date:
2016-07-15
DOI:
EISSN:
1865-5785
ISSN:
1868-9256
Pubs id:
pubs:655623
URN:
uri:1d5c786c-89f8-475e-ba9b-6ec372d0c5df
UUID:
uuid:1d5c786c-89f8-475e-ba9b-6ec372d0c5df
Local pid:
pubs:655623
Language:
English
Keywords:

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