A high-sensitivity HPLC assay for measuring intracellular Na+ and K+ and its application to Plasmodium falciparum infected erythrocytes
- The measurement of intracellular ion concentrations, and the screening of chemical agents to identify molecules targeting ion transport, has traditionally involved low-throughput techniques. Here we present a novel HPLC method that allows the rapid, high-sensitivity measurement of cell Na+ and K+ content, demonstrating its utility by monitoring the ionic changes induced in the intracellular malaria parasite by the new spiroindolone antimalarial KAE609.
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Copyright holder:
- Winterberg and Kirk
- Copyright date:
- This work is licensed under a Creative Commons Attribution 4.0 International License.
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