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A high-sensitivity HPLC assay for measuring intracellular Na+ and K+ and its application to Plasmodium falciparum infected erythrocytes

Abstract:
The measurement of intracellular ion concentrations, and the screening of chemical agents to identify molecules targeting ion transport, has traditionally involved low-throughput techniques. Here we present a novel HPLC method that allows the rapid, high-sensitivity measurement of cell Na+ and K+ content, demonstrating its utility by monitoring the ionic changes induced in the intracellular malaria parasite by the new spiroindolone antimalarial KAE609.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep29241

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Publication date:
2016-07-07
Acceptance date:
2016-06-14
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
629980
Pubs id:
pubs:629980
UUID:
uuid:1d5c0ebc-0b32-4845-92e2-8155c915b892
Local pid:
pubs:629980
Deposit date:
2016-06-27

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