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A high-sensitivity HPLC assay for measuring intracellular Na+ and K+ and its application to Plasmodium falciparum infected erythrocytes

Abstract:
The measurement of intracellular ion concentrations, and the screening of chemical agents to identify molecules targeting ion transport, has traditionally involved low-throughput techniques. Here we present a novel HPLC method that allows the rapid, high-sensitivity measurement of cell Na+ and K+ content, demonstrating its utility by monitoring the ionic changes induced in the intracellular malaria parasite by the new spiroindolone antimalarial KAE609.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep29241

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Publication date:
2016-07-07
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
uuid:1d5c0ebc-0b32-4845-92e2-8155c915b892
Source identifiers:
629980
Local pid:
pubs:629980

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