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Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor.

Abstract:

BACKGROUND: Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-Inducible Factor). Little is known regarding HIF expression and function in primary bone sarcomas. We describe HIF expression and phenotypic effects of hypoxia, hypoglycaemia and HIF in Ewing's sarcoma and osteosarcoma. METHODS: HIF-1alpha and HIF-2alpha immunohistochemistry was performed on a Ewing's tumour tissue array. Ewing's sarcoma and osteosarcoma cell lines were assessed for HIF pathway induction ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2407-10-372

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Name:
National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit
Funding agency for:
Knowles, H
Athanasou, N
Grant:
BCRT/06/08
BCRT/06/08
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Name:
Bone Cancer Research Trust
Funding agency for:
Knowles, H
Athanasou, N
Grant:
BCRT/06/08
BCRT/06/08
More from this funder
Name:
European Commission - EuroBoNeT
Grant:
LSHCCT-2006-018 814
Publisher:
BioMed Central
Journal:
BMC cancer More from this journal
Volume:
10
Issue:
1
Pages:
372
Publication date:
2010-07-16
DOI:
EISSN:
1471-2407
ISSN:
1471-2407

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