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Activation of caspase-3 in permanent and transient brain ischaemia in man.

Abstract:

Animal studies have shown brain ischaemia to cause oxidative damage to DNA and activation of caspase-3, leading to apoptosis. These changes may be exacerbated by reperfusion. To assess caspase-3 activation after transient and permanent brain ischaemia in man, we examined brain tissue from patients who had experienced a cardiac arrest with resuscitation or an atherothrombotic brain infarct, and died 12 h to 9 days later. Sections were immunostained for activated caspase-3 or the 89 kDa caspase...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Neuroreport
Volume:
11
Issue:
11
Pages:
2495-2499
Publication date:
2000-08-01
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
Source identifiers:
31736

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