- Abstract:
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SETD2/HYPB (SET domain−containing protein 2 / Huntingtin yeast partner B) is the predominant lysine methyltransferase in mammals that mediates histone H3 lysine-36 (H3K36) trimethylation, which is associated with transcription elongation and RNA splicing. SETD2 is further implicated in p53 function, vascular development, cancer progression and, through Huntingtin-interaction, Huntington's disease. Although different transcripts and putative protein isoforms have been detected previously, t...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
-
uuid:1d4e55de-20c8-4a72-aea1-6af51c0a8e6b
- Local pid:
- ora:12066
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Lee, BM
- Copyright date:
- 2011
Thesis
Identification and characterisation of alternative forms of SETD2/HYPB (SET domain-containing protein 2 / Huntingtin yeast partner B)
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Authors
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+ Mahadevan, LC
+ Mancini, EJ
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