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Thesis

Identification and characterisation of alternative forms of SETD2/HYPB (SET domain-containing protein 2 / Huntingtin yeast partner B)

Abstract:

SETD2/HYPB (SET domain−containing protein 2 / Huntingtin yeast partner B) is the predominant lysine methyltransferase in mammals that mediates histone H3 lysine-36 (H3K36) trimethylation, which is associated with transcription elongation and RNA splicing. SETD2 is further implicated in p53 function, vascular development, cancer progression and, through Huntingtin-interaction, Huntington's disease. Although different transcripts and putative protein isoforms have been detected previously, t...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Wolfson College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Grant:
Funding agency for:
Lee, BM
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1d4e55de-20c8-4a72-aea1-6af51c0a8e6b
Local pid:
ora:12066

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