Thesis
Identification and characterisation of alternative forms of SETD2/HYPB (SET domain-containing protein 2 / Huntingtin yeast partner B)
- Abstract:
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SETD2/HYPB (SET domain−containing protein 2 / Huntingtin yeast partner B) is the predominant lysine methyltransferase in mammals that mediates histone H3 lysine-36 (H3K36) trimethylation, which is associated with transcription elongation and RNA splicing. SETD2 is further implicated in p53 function, vascular development, cancer progression and, through Huntingtin-interaction, Huntington's disease. Although different transcripts and putative protein isoforms have been detected previously, t...
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Authors
Contributors
+ Mahadevan, LC
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Mancini, EJ
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:1d4e55de-20c8-4a72-aea1-6af51c0a8e6b
- Local pid:
- ora:12066
- Deposit date:
- 2015-08-03
Terms of use
- Copyright holder:
- Lee, BM
- Copyright date:
- 2011
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