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Journal article

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding.

Abstract:

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin (NB-DNJ) is a potent inhibitor of human immunodeficiency virus (HIV) replication and syncytium formation in vitro. However, the exact mechanism of action of NB-DNJ remains to be determined. In this study we have examined the impairment of HIV infectivity mediated by NB-DNJ. By two independent HIV entry assays [PCR-based HIV entry assay and entry of Cocal(HIV) pseudotypes], the reduction in infectivity was found to be due to an impairment...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
69
Issue:
9
Pages:
5791-5797
Publication date:
1995-09-01
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:26422
UUID:
uuid:1d3bbfbd-c744-4092-8268-f20c369b7b11
Local pid:
pubs:26422
Source identifiers:
26422
Deposit date:
2012-12-19

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