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Journal article

Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

Abstract:

Genotype imputation is potentially a zero-cost method for bridging gaps in coverage and power between genotyping platforms. Here, we quantify these gains in power and coverage by using 1,376 population controls that are from the 1958 British Birth Cohort and were genotyped by the Wellcome Trust Case-Control Consortium with the Illumina HumanHap 550 and Affymetrix SNP Array 5.0 platforms. Approximately 50% of genotypes at single-nucleotide polymorphisms (SNPs) exclusively on the HumanHap 550 c...

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Publication status:
Published

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Publisher copy:
10.1016/j.ajhg.2008.06.008

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Journal:
American journal of human genetics
Volume:
83
Issue:
1
Pages:
112-119
Publication date:
2008-07-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:1d37de02-0eef-4d5b-a761-1d3549b0472a
Source identifiers:
34291
Local pid:
pubs:34291

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