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Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment.

Abstract:
Radiotherapy sensitizes unresponsive tumors to the antineoplastic activity of antibodies that target the inhibitory receptor CTLA-4 on T cells. One molecular mechanism accounting for this therapeutic synergy is the induction of NKG2D ligands on irradiated tumor cells. The fact that NKG2D receptors must be engaged for the elicitation of CD8(+) T-cell antitumor responses has important clinical implications.

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Publisher copy:
10.4161/onci.23127

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Oncoimmunology More from this journal
Volume:
2
Issue:
3
Pages:
e23127
Publication date:
2013-03-01
DOI:
EISSN:
2162-402X
ISSN:
2162-4011
Language:
English
Keywords:
Pubs id:
pubs:426231
UUID:
uuid:1d370b99-0ed0-4d55-8534-4f4454d93f2e
Local pid:
pubs:426231
Source identifiers:
426231
Deposit date:
2014-07-10

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