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Induction of DNA strand breaks, base lesions and clustered damage sites in hydrated plasmid DNA films by ultrasoft X rays around the phosphorus K edge.

Abstract:

To characterize the DNA damage induced by K-shell ionization of phosphorus atom in DNA backbone on the level of hydration, the yields of DNA strand breaks and base lesions arising from the interaction of ultrasoft X rays with energies around the phosphorus K edge were determined using dry and fully hydrated pUC18 plasmid DNA samples. Base lesions and bistranded clustered DNA damage sites were revealed by postirradiation treatment with the base excision repair proteins endonuclease III (Nth) a...

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Publication status:
Published

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Publisher copy:
10.1667/rr1609.1

Authors


Cunniffe, SM More by this author
Watanabe, R More by this author
Kobayashi, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Radiation research
Volume:
172
Issue:
3
Pages:
296-305
Publication date:
2009-09-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:1d3664b8-3f29-4b9f-a738-4e83e5156e48
Source identifiers:
131227
Local pid:
pubs:131227

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