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Journal article

Exposure to zidovudine adversely affects mitochondrial turnover in primary T cells.

Abstract:

Zidovudine (ZDV) is a widely used component of antiretroviral therapy (ART) in resource-limited settings, despite its known adverse effects, which include mitochondrial toxicity in muscle, liver and adipose tissue. It has also been associated with impaired immunological recovery. We hypothesised that ZDV might impair mitochondrial health and survival of primary T cells. We performed a cross-sectional analysis of mitochondrial function, mitophagy and susceptibility to apoptosis in healthy dono...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Department:
Wadham College
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
More by this author
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
Publisher:
Elsevier-Masson Publisher's website
Journal:
Antiviral Research Journal website
Volume:
133
Issue:
6
Pages:
178-182
Publication date:
2016-08-02
DOI:
EISSN:
1872-9096
ISSN:
0166-3542
Pubs id:
pubs:638172
URN:
uri:1d26e425-f0cd-4cfc-8e1a-82ba80a86b2c
UUID:
1d26e425-f0cd-4cfc-8e1a-82ba80a86b2c
Local pid:
pubs:638172

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