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Exposure to zidovudine adversely affects mitochondrial turnover in primary T cells.

Abstract:

Zidovudine (ZDV) is a widely used component of antiretroviral therapy (ART) in resource-limited settings, despite its known adverse effects, which include mitochondrial toxicity in muscle, liver and adipose tissue. It has also been associated with impaired immunological recovery. We hypothesised that ZDV might impair mitochondrial health and survival of primary T cells. We performed a cross-sectional analysis of mitochondrial function, mitophagy and susceptibility to apoptosis in healthy dono...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Wadham College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
National Institute for Health Research Biomedical Research Centre Programme More from this funder
Nuffield Department of Medicine More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Antiviral Research Journal website
Volume:
133
Issue:
6
Pages:
178-182
Publication date:
2016-08-02
Acceptance date:
2016-08-01
DOI:
EISSN:
1872-9096
ISSN:
0166-3542
Source identifiers:
638172
Language:
English
Keywords:
Pubs id:
pubs:638172
UUID:
uuid:1d26e425-f0cd-4cfc-8e1a-82ba80a86b2c
Local pid:
pubs:638172
Deposit date:
2016-08-18

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