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Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping.

Abstract:

The androgen receptor (AR) ligand-binding domain (LBD) binds FXXLF motifs, present in the AR N-terminal domain and AR-specific cofactors, and some LXXLL motifs of nuclear receptor coactivators. We demonstrated that in the context of the AR FXXLF motif many different amino acid residues at positions +2 and +3 are compatible with strong AR LBD interaction, although a preference for E at +2 and K or R at +3 was found. Pairwise systematic analysis of F/L swaps at +1 and +5 in FXXLF and LXXLL moti...

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Publication status:
Published

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Publisher copy:
10.1210/me.2005-0348

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Journal:
Molecular endocrinology (Baltimore, Md.)
Volume:
20
Issue:
8
Pages:
1742-1755
Publication date:
2006-08-05
DOI:
EISSN:
1944-9917
ISSN:
0888-8809
URN:
uuid:1d247cf9-9689-47da-97ad-3dfdf8043733
Source identifiers:
285059
Local pid:
pubs:285059

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