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Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.

Abstract:

uPA (urokinase-type plasminogen activator) stimulates cell migration through multiple pathways, including formation of plasmin and extracellular metalloproteinases, and binding to the uPAR (uPA receptor; also known as CD87), integrins and LRP1 (low-density lipoprotein receptor-related protein 1) which activate intracellular signalling pathways. In the present paper we report that uPA-mediated cell migration requires an interaction with fibulin-5. uPA stimulates migration of wild-type MEFs (mo...

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Publisher copy:
10.1042/bj20110348

Authors


Kapustin, A More by this author
Stepanova, V More by this author
Poliakov, A More by this author
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Journal:
The Biochemical journal
Volume:
443
Issue:
2
Pages:
491-503
Publication date:
2012-04-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:1d1c3335-2b5c-4c5c-a02e-4d61ebdf4395
Source identifiers:
246282
Local pid:
pubs:246282

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