- Abstract:
-
To date many clinical studies aim to increase the number and/or fitness of CD4(+)CD127(low)CD25(+) regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4(+)CD127(low)CD25(+) TIGIT(-) T cells distinguished by their elevated IL-6R expression that lacked expression of HELIOS, s...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(zip, 1.6mb)
-
(pdf, 2.6mb)
-
- Publisher copy:
- 10.1016/j.clim.2017.03.002
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Clinical Immunology Journal website
- Volume:
- 179
- Pages:
- 25-39
- Publication date:
- 2017-03-09
- Acceptance date:
- 2017-03-07
- DOI:
- EISSN:
-
1521-6616
- ISSN:
-
1521-7035
- Pubs id:
-
pubs:685480
- URN:
-
uri:1d1bf428-2952-4323-bc24-4d3a32e54ffc
- UUID:
-
uuid:1d1bf428-2952-4323-bc24-4d3a32e54ffc
- Local pid:
- pubs:685480
- Language:
- English
- Keywords:
- Copyright holder:
- ©Ferreira, et al
- Copyright date:
- 2017
- Notes:
- This is an open access article published under a creative commons license, see: https://creativecommons.org/licenses/by/4.0/
Journal article
Human IL-6R(hi)TIGIT(-) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile
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