Journal article icon

Journal article

Human IL-6R(hi)TIGIT(-) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile

Abstract:

To date many clinical studies aim to increase the number and/or fitness of CD4(+)CD127(low)CD25(+) regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4(+)CD127(low)CD25(+) TIGIT(-) T cells distinguished by their elevated IL-6R expression that lacked expression of HELIOS, s...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.clim.2017.03.002

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Juvenile Diabetes Research Foundation
Funding agency for:
Ferreira, R
Grant:
3-APF-2015-88-A-N
2-APF-2017-420-A-N
More from this funder
Name:
Wellcome Trust
Grant:
WT083650/Z/07/Z
Publisher:
Elsevier
Journal:
Clinical Immunology More from this journal
Volume:
179
Pages:
25-39
Publication date:
2017-03-09
Acceptance date:
2017-03-07
DOI:
EISSN:
1521-6616
ISSN:
1521-7035
Language:
English
Keywords:
Pubs id:
pubs:685480
UUID:
uuid:1d1bf428-2952-4323-bc24-4d3a32e54ffc
Local pid:
pubs:685480
Source identifiers:
685480
Deposit date:
2017-05-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP