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GAL4 enhancer trap targeting of the Drosophila sex determination gene fruitless.

Abstract:

The fru4 allele of the sex determination gene fruitless is induced by insertion of a P[lacZ,ry+] enhancer trap element. This insert also acts to disrupt expression of the fru P1 promoter derived male-specific proteins, consequently impairing male courtship behavior. fru4 maps less than 2 kb upstream of the fru P3 promoter, whose function is essential for viability. We replaced this insert with a GAL4 element, P[GAL4,w+], recovering two lines with insertions in opposite orientations at the loc...

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Publication status:
Published

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Publisher copy:
10.1002/gene.20143

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Genesis (New York, N.Y. : 2000)
Volume:
42
Issue:
4
Pages:
236-246
Publication date:
2005-08-05
DOI:
EISSN:
1526-968X
ISSN:
1526-954X
URN:
uuid:1d131ec9-ab46-4417-83bf-875dc4d9b458
Source identifiers:
315584
Local pid:
pubs:315584

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