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Journal article

HIV control through a single nucleotide on the HLA-B locus.

Abstract:

Genetic variation within the HLA-B locus has the strongest impact on HIV disease progression of any polymorphisms within the human genome. However, identifying the exact mechanism involved is complicated by several factors. HLA-Bw4 alleles provide ligands for NK cells and for CD8 T cells, and strong linkage disequilibrium between HLA class I alleles complicates the discrimination of individual HLA allelic effects from those of other HLA and non-HLA alleles on the same haplotype. Here, we expl...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01020-12

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Journal:
Journal of virology
Volume:
86
Issue:
21
Pages:
11493-11500
Publication date:
2012-11-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:1d0b7dd4-4fc0-4479-bb77-f4c35a3ee111
Source identifiers:
345595
Local pid:
pubs:345595

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