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Journal article

Germline variation in inflammation-related pathways and risk of Barrett’s esophagus and esophageal adenocarcinoma

Abstract:

Objective:
Esophageal adenocarcinoma (EA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to EA pathogenesis. Established risk factors for EA and its precursor, Barrett’s esophagus (BE), include symptomatic reflux, obesity, and smoking. The role of inherited genetic susceptibility remains an area of active investigation. Here, we explore whether germline variation related to inflammatory process...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1136/gutjnl-2016-311622

Authors


Johnson, LG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Gut Journal website
Publication date:
2016-08-02
DOI:
EISSN:
0017-5749
ISSN:
1468-3288
URN:
uuid:1d07567d-db17-4737-8586-53d7f27390f5
Source identifiers:
633498
Local pid:
pubs:633498

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