Germline variation in inflammation-related pathways and risk of Barrett’s esophagus and esophageal adenocarcinoma
Esophageal adenocarcinoma (EA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to EA pathogenesis. Established risk factors for EA and its precursor, Barrett’s esophagus (BE), include symptomatic reflux, obesity, and smoking. The role of inherited genetic susceptibility remains an area of active investigation. Here, we explore whether germline variation related to inflammatory process...
- Publication status:
- Peer review status:
- Peer reviewed
- Accepted manuscript
- Copyright holder:
- Buas et al.
- Copyright date:
- This is the accepted manuscript version of the article. The final version is available online from BMJ Publishing Group at: [10.1136/gutjnl-2016-311622]
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