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Journal article

Germline variation in inflammation-related pathways and risk of Barrett’s esophagus and esophageal adenocarcinoma

Abstract:

Objective:
Esophageal adenocarcinoma (EA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to EA pathogenesis. Established risk factors for EA and its precursor, Barrett’s esophagus (BE), include symptomatic reflux, obesity, and smoking. The role of inherited genetic susceptibility remains an area of active investigation. Here, we explore whether germline variation related to inflammatory process...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/gutjnl-2016-311622

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
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Name:
National Institutes of Health
Grant:
R21DK099804
R01CA136725
Publisher:
BMJ Publishing Group
Journal:
Gut More from this journal
Publication date:
2016-08-02
Acceptance date:
2016-07-02
DOI:
EISSN:
0017-5749
ISSN:
1468-3288
Keywords:
Pubs id:
pubs:633498
UUID:
uuid:1d07567d-db17-4737-8586-53d7f27390f5
Local pid:
pubs:633498
Source identifiers:
633498
Deposit date:
2016-07-12

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