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Journal article

Quantification of the antimalarial drug pyronaridine in whole blood using LC-MS/MS - increased sensitivity resulting from reduced non-specific binding

Abstract:

Malaria is one of the most important parasitic diseases of man. The development of drug resistance in malaria parasites is an inevitable consequence of their widespread and often unregulated use. There is an urgent need for new and effective drugs. Pyronaridine is a known antimalarial drug that has received renewed interest as a partner drug in artemisinin-based combination therapy. To study its pharmacokinetic properties, particularly in field settings, it is necessary to develop and validat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jpba.2017.08.023

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
St Catherine's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
091901/Z/10/Z
Publisher:
Elsevier
Journal:
Journal of pharmaceutical and biomedical analysis More from this journal
Volume:
146
Pages:
214-219
Publication date:
2017-08-26
Acceptance date:
2017-08-17
DOI:
EISSN:
1873-264X
ISSN:
0731-7085
Pmid:
28886522
Language:
English
Keywords:
Pubs id:
pubs:727781
UUID:
uuid:1cfd0fb4-8510-433b-a6b0-8e671d42969a
Local pid:
pubs:727781
Source identifiers:
727781
Deposit date:
2017-09-13

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