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Journal article

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains.

Abstract:

Transmembrane adaptor molecule LAT (linker for activation of T cells) forms a central scaffold for signaling protein complexes that accumulate in the vicinity of activated T cell antigen receptors (TCR). Here we used biochemical analysis of immunoisolated plasma membrane domains and fluorescence imaging of green fluorescence protein-tagged signaling proteins to investigate the contributions of different tyrosine-based signaling protein docking sites of LAT to the formation of LAT signaling pr...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m301212200

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Journal:
The Journal of biological chemistry
Volume:
278
Issue:
22
Pages:
20389-20394
Publication date:
2003-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:1cf852f4-e98a-49fb-b17f-4a84bc17a3d7
Source identifiers:
30021
Local pid:
pubs:30021

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