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Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.

Abstract:

The absence of expression of class I products of the major histocompatibility complex at early stages of development is thought to play a key role in maternal tolerance of the fetal allograft. To test this, we developed a strategy that would allow us to describe the consequences of overexpression of the H-2Dd transplantation antigen in the developing embryo. A construct containing the H-2Dd gene under control of the human beta-actin promoter was transfected into pluripotent embryonic stem (ES...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.89.13.5927

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
89
Issue:
13
Pages:
5927-5931
Publication date:
1992-07-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:25778
UUID:
uuid:1cf14758-a853-46f5-a232-26410ef288bc
Local pid:
pubs:25778
Source identifiers:
25778
Deposit date:
2012-12-19

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