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Accumulating research: a systematic account of how cumulative meta-analyses would have provided knowledge, improved health, reduced harm and saved resources

Abstract:

Background “Cumulative meta-analysis” describes a statistical procedure to calculate, retrospectively, summary estimates from the results of similar trials every time the results of a further trial in the series had become available. In the early 1990s, comparisons of cumulative meta-analyses of treatments for myocardial infarction with advice promulgated through medical textbooks showed that research had continued long after robust estimates of treatment effects had accumulated, and that med...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0102670

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
9
Issue:
7
Pages:
ARTN e102670
Publication date:
2014-07-28
Acceptance date:
2014-06-20
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:1cf07969-2bd9-47b6-9613-1703ea65ef80
Local pid:
pubs:478966
Source identifiers:
478966
Deposit date:
2014-08-16

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