Thesis
Understanding immunity differences induced by whole cell and acellular pertussis vaccines in a paediatric population
- Alternative title:
- Immunity differences between pertussis vaccines
- Abstract:
-
Bordetella pertussis causes whooping cough, a life-threatening disease in infants. Both whole cell (wP) and acellular (aP) vaccines are used for infant immunisation with aP providing less robust long-term population protection. To further understand differences between wP and aP, this thesis aims: to characterise the immune response to an aP-booster in a UK cohort by age and priming backgrounds (wP/aP) using a broad variety of assays of humoral immunity; to investigate effect of HLA-DRB1-2...
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Authors
Contributors
+ Pollard, A
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Contributor
ORCID:
0000-0001-7361-719X
+ Snape, M
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Contributor
+ Clutterbuck, E
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Supervisor
ORCID:
0000-0003-1701-1390
+ Mentzer, A
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
ORCID:
0000-0002-4502-2209
+ Kelly, D
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Supervisor
Funding
+ National Institute for Health Research
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Funding agency for:
Snape, M
Grant:
039/0031
Programme:
Sched 3 study
+ European Union’s seventh Framework program
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Funding agency for:
Pollard, A
Grant:
279185
Programme:
EUCLIDS study
+ Innovative Medicines Initiative 2 joint Undertaking and Bill and Melinda Gates Foundation
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Funding agency for:
Pollard, A
Grant:
115910
Programme:
The Periscope (PERtussIS COrrelate of Protection Europe
+ Oxfordshire Health Services Research Committee OHSRC
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Funding agency for:
Martins Valente Pinto, AM
Grant:
1297 Apr-18
+ Oxford-Hoffmann Graduate Scholarship in Medical Sciences
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Funding agency for:
Martins Valente Pinto, AM
Grant:
16/17_MSD_1048879
16/17_MSD_1048879
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2021-08-30
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Terms of use
- Copyright holder:
- Martins Valente Pinto, AM
- Copyright date:
- 2021
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