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Journal article

2-Oxoglutarate oxygenases are inhibited by a range of transition metals.

Abstract:
2-Oxoglutarate oxygenases are inhibited by a range of transition metals, as exemplified by studies on human histone demethylases and prolyl hydroxylase domain 2 (PHD2 or EGLN1). The biological effects associated with 2-oxoglutarate oxygenase inhibition may result from inhibition of more than one enzyme and by mechanisms in addition to simple competition with the Fe(ii) cofactor.
Publication status:
Published

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Publisher copy:
10.1039/c004952b

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Metallomics : integrated biometal science More from this journal
Volume:
2
Issue:
6
Pages:
397-399
Publication date:
2010-06-01
DOI:
EISSN:
1756-591X
ISSN:
1756-5901
Language:
English
Keywords:
Pubs id:
pubs:60682
UUID:
uuid:1cd5e675-e0dc-444a-80e9-bdd744c6613f
Local pid:
pubs:60682
Source identifiers:
60682
Deposit date:
2012-12-19

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