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Journal article

The histamine-synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin.

Abstract:

BACKGROUND: Histamine is an abundant mediator accumulating in the skin of atopic patients, where it is thought to be derived from immune cells. While keratinocytes express histidine decarboxylase (HDC), levels of the enzyme in normal or diseased epidermis and factors that influence its expression in human keratinocytes are not known. OBJECTIVES: To assess levels of HDC in inflammatory skin diseases and factors influencing its expression. METHODS: Normal and filaggrin-insufficient human kerati...

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Publication status:
Published

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Publisher copy:
10.1111/bjd.13199

Authors


Gutowska-Owsiak, D More by this author
Greenwald, L More by this author
Selvakumar, TA More by this author
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Publisher:
Blackwell Publishing Ltd
Journal:
The British journal of dermatology
Volume:
171
Issue:
4
Pages:
771-778
Publication date:
2014-10-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:1cd57706-e994-4b83-8006-689e0826fa48
Source identifiers:
471043
Local pid:
pubs:471043
Language:
English

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