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Thesis

Screen for proteins that regulate sensitivity to inhibition of the insulin-like growth factor 1 receptor

Abstract:

The type 1 insulin-like growth factor receptor (IGF-1R) plays a significant role in tumor growth and spread, and IGF-1R inhibitors and antibodies are now undergoing clinical testing. However, factors that regulate sensitivity to IGF-1R inhibition remain unclear. The aim of this project is to identify proteins whose depletion regulates sensitivity to IGF-1R inhibition, in order to design effective combination treatments to benefit patients. An IGF-1R kinase inhibitor, AZ12253801 (provided b...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of
Role:
Author

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Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
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