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Thesis

Linking glucocorticoid action and hypoxia: a novel mechanism driving an adverse metabolic phenotype?

Abstract:

Obstructive sleep apnoea (OSA) is characterised by repeated cycles of reduced and complete obstruction of air flow occurring in sleep. This can result in decreased oxygen levels (hypoxia). OSA and states of glucocorticoid excess are both associated with metabolic diseases including fatty liver disease. Whether increased glucocorticoids are a feature of OSA and may contribute to the increased metabolic risk seen in OSA is unknown.

In vitro, patient and healthy volunteer stud...

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Division:
MSD
Department:
RDM
Role:
Author

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Supervisor
Role:
Supervisor
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Name:
Wellcome Trust Clinical Research Training Fellowship
Grant:
WT104458AIA
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1cce0b41-a2f0-4a6d-9982-aabc2f762935
Deposit date:
2019-09-03

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