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Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells.

Abstract:

The ability of NK cells to kill tumor cells is controlled by a balance between activating and inhibitory signals transduced by distinct receptors. In murine tumor models, the costimulatory molecule B7.1 not only acts as a positive trigger for NK-mediated cytotoxicity but can also overcome negative signaling transduced by MHC class I molecules. In this study, we have evaluated the potential of human B7.1-CD28 interaction as an activating trigger for human blood NK cells. Using multiparameter f...

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Publication status:
Published

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Journal:
Journal of Immunology More from this journal
Volume:
163
Issue:
1
Pages:
62-70
Publication date:
1999-07-01
EISSN:
1550-6606
ISSN:
0022-1767

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